So we have more good news and some puzzling news, and I'm hoping some of my science buddies can give me a hand?
After I had the nuchal test, I went down for the blood test to the lab, and they sent it off. I had some results pretty quick, but they only print out the results for Down's on the printout and I also wanted the risks for Trisomy 18 & 13 and well any numbers they can get me, right?
Now realistically, the nuchal test is the only thing that matters when we discuss the health or chromosomes of the baby. It's the biggie. The blood tests, the Papp-A, the free beta hcg, the inhibin A, all the rest of them, only point to placental health, which can be an indicator of fetal problems but not a guarantee one way or the other. This is why most of the blood screening tests have such a high false positive rate btw, because while it is possible to have a damaged placenta and a healthy baby with no anomalies, it's almost completely impossible to have a totally healthy placenta and a baby who has serious birth defects. (And I'm not excluding situations like molar pregnancies, where you have a placenta that works and no baby at all, just a sac, really. The placentas work for a while, but structurally they are still bad, which is why they fail eventually.)
Unfortunately, my history has gone for almost every variation. Healthy kids - my boys, who had iffy placentas, but by some random chance, lived. Matthew, who was chromosomally damaged, and had a bad placenta, and died. Georgia and Mira, who were chromosomally perfect, no birth defects, no problems, but whose placentas were so very damaged that they had absolutely no hope of ever making it, and died in utero.
So now, I'm staring at the damn numbers and the genetics people have told me they are great for chromosomes, and I'm thinking, whew....one hump over, and now the next hump, what about my placenta? So if any of you can tell me or give me links to charts or figure out what these numbers mean for my placental health or risk of miscarriage or IUGR, or well any old outcome, I'd be so grateful, I'd have your baby!!! Whoops, scratch that, not my best skill----errrr, I'll give you lots of hugs and blogkisses!!!!!
Or something really really neat!!!!
And yes I'm supposed to meet with Dr.Placenta next week some time but that's freakin' NEXT WEEK. I can't wait that long.
So at 12 weeks, 1 day DinkyPie's numbers were:
CRL - 65 mm
NT - 1.3 mm
BPD - 19mm
Free beta hcg was 21.3 iu/l (international units per litre) leading to a risk factor they call Multiple of the Median or MoM of 0.53.
PAPP-A was 1.98 iu/l leading to a risk factor of .66 MoM.
(Yes, the ratio is called MoM, literally what is the risk we will or won't get to be a Mom. Why do I just freakin' KNOW a non-Stirrup Queen decided to use that acronym for this criteria? *eyeroll*)
If an average 39 year old woman had these numbers she'd have a risk of Down's that is 1 in 5290, and a risk of Trisomy 18 or 13 of 1 in 73,500. Since I previously had a child with Trisomy 18, my risk goes up by 0.75% and slightly changes these odds, but they are still pretty great.
I'm getting an amnio anyway, since 1 in 73,000 isn't much comfort if you're the one, and well, I was the one. I have this nightmare that something will show up on an anatomy scan, something innocuous like a choroid plexus cyst, like Mac had, and I'll be terrified unless I know the chromosomes are perfect. Frankly, these days I wonder if a cyst like that is a sign of brilliance, or artistic ability since Mac is so smart and so amazing at drawing. Ehh, who knows?
So does anyone know if that PAPP-A level is low or high, or good or bad in terms of pregnancy outcomes? Or have access to charts or scientific articles with the tables attached? Links, please?
Even Wikipedia is blank on this one. Totally blank, useless, crazy making..... yes if any wikipedians are out there, feel free to fix that!!
I'm going to go eat some pickles now. Ta-ta.